Mitragynine Pseudoindoxyl: Breaking Down this New Alkaloid

Whether you’re a beginner kratom user or a seasoned enthusiast, you’re a fan of the unique properties from Mitragyna speciosa, the evergreen tree that produces kratom. These properties are rooted in the plant’s alkaloids, primarily mitragynine and 7-hydroxymitragynine. But one relatively new alkaloid has attracted a lot of attention: mitragynine pseudoindoxyl.

Alkaloids in Kratom

Among the many alkaloids in kratom, the two found in the highest concentration are mitragynine and 7-hydroxymitragynine. Mitragynine pseudoindoxyl is considered a minor alkaloid but that doesn’t mean it’s not important.

Mitragynine

Mitragynine has been a subject of research for some time. It stimulates μ opioid receptors of the brain, which may be one of the reasons for its popularity both in scientific and consumer settings.

7-Hydroxymitragynine

This compound is a metabolite of mitragynine. It occurs naturally and is produced when the body metabolizes mitragynine. It shares qualities similar to mitragynine and may offer moderate benefits.

Mitragynine Pseudoindoxyl

Mitragynine pseudoindoxyl is a powerful active metabolite of mitragynine. According to one article, this alkaloid:

“Acts not as a single molecular entity but as a dynamic ensemble of stereoisomers in protic environments, thus, it exhibits structural plasticity in biological systems. Accordingly, these synthetic, structural, and biological studies provide a basis for the planned design of mitragynine pseudoindoxyl analogs, which can guide the development of next-generation analgesics.”

In short, this means mitragynine pseudoindoxyl may hold an important key for developing more effective ways to help manage discomfort.

Pharmacological Aspects

This popular, new alkaloid works in multiple roles with neuroreceptors, acting simultaneously as an agonist and an antagonist.

An agonist binds to a neuroreceptor in the same way as a naturally produced neurotransmitter or hormone and prompts a similar reaction. An antagonist does the opposite, it binds to a location on a receptor and blocks other neurotransmitters from interacting with that same location. This serves to halt or decrease the effect of specific neurotransmitters.

In addition to its dual role as an agonist and an antagonist, the alkaloid acts as a G protein-biased agonist that activates G protein-coupled receptors (GPCRs), which are the largest group of cell surface receptors in the human body. A G protein-biased agonist can selectively activate neural pathways that lead to positive benefits while avoiding pathways associated with negative effects.

Potential Benefits (Based on Customer Reviews)

Mitragynine pseudoindoxyl has had a variety of positive reviews from customers.

Temporary relief from discomfort – This alkaloid may make kratom better at soothing discomfort, a property that is especially strong in red kratom strains.

Enhanced energy – Products with high levels of this alkaloid may help kratom be more energizing for some users.

Better focus and attention – This new alkaloid may increase kratom’s reported ability to help users concentrate better or power through important tasks.

Mood-boosting – Some users may discover kratom powders with high mitragynine and mitragynine pseudoindoxyl content to be uplifting and benefit their state of mind.

Supports learning – The nootropic effects of kratom may support cognitive functions and the addition of this alkaloid could help with learning-related tasks like studying or planning.

Improve Your Lifestyle With The Kratom Company

If you need a boost of energy in the morning, help with focus, or you are feeling a little low, try

a kratom product with a high concentration of mitragynine pseudoindoxyl, like our Red Liquid Kratom Extract. A bottle of kratom extract is easy to carry and store in your pantry or medicine chest.

Learn more about kratom on our blog, or buy kratom now and we can have your order shipped in a single business day!